Sample Description Pressure [psi] #Pass Results & Comments
Meningicoccal cell paste
(4%) in buffer
1,000 1 Cooling used to maintain 10℃ temperature. Complete rupture achieved in one pass.

Mammalian cells 2,000 1 Complete rupture of cells and easy seperation of parasite within the cell achieved in one pass on laboratory model HC-5000

E. coli (1-10%) in buffer

6,000 3 90% rupture achieved. Results scaled linearly from lab to production.

10,000 1 90% rupture achieved.

1,000 3 90% rupture achieved.

Baker's yeast 20,000 10 Cooling used. 95% rupture of yeast cells achieved.

Brewer's yeast (10%)
in water
10,000 1 to 10 Cooling used. 95% rupture of yeast cells achieved.

20,000 1 to 10 71% rupture at 1 pass and 98% in 10 passes. Yield of enzyme significantly better than that acheived with other processing techniques including French press.
 
크기 ; L×W×H (cm)
Sample Description Pressure [psi] #Pass Results & Comments
Veterinary vaccine 25%
W/O vaccine with
inactivated bacteria
1,000 1 All particles < 1.0 microns-Average particle size: 0.1㎛ -Antigen efficacy increase 5-10 times
Vaccine adjuvant for influenza virus vaccineTetronic 1501 2.5% Squalane 5.0%
Tween 800.2% P.B.S. q.s.
10,000 2 to 10 Particle size: all < 0.3㎛Patented adjuvant.
Liposomes encapsulatinga dye maker for diagnostictests. 4,000 1 0.3-0.4㎛ liposomesDistribution tightened.Mat'l run at 45℃. Above results considered success since tight size control required to produce a reliable diagnostic test kit.
4,000 4
20% Soy LecithinLiposomes 5,000 1 Particle size: 0.118㎛
10,000 1 Particle size: 0.101㎛
15,000 1 Particle size: 0.091㎛
Incomplete Freud's Adjuvant (W/O emulsion)
Lt mineral oil 72.0%
Arlacel A 8.0%
D.I. Water 19.2%
Tween80 0.8%
200 1 Particle size: most 1-3㎛,some 2-4㎛, very few at 5㎛No coalescence of water droplets seen after several weeks of stability testing.
 
 
Sample Description Pressure [psi] #Pass Results & Comments
Peanut Butter 3,000 3 Heated sample to 85-90F.Particle size reduced from 5-50㎛ to a good distribution at 20㎛ Smooth creamy product resulted.
Non-dairy chocolate base 5,000 1 to 3 Heated sample to 125-150F.Sample did not separate on standing. Sample was also noticeably thicker. Desired stability and viscosity achieved
Non-fat ice cream
Proprietary formulation
18,200 1 Particle size data:-Start: 0.42㎛+/- 47%-1 pass: 0.23㎛+/- 27%Mouthfeel was noticeable smoother and creamier.
Starch powder in water 7,000 1 Material started as grainy dispersion and became smooth and semi-translucent after one pass. Marked viscosity increase from starting mat'l being like a thin batter and the processed mat'l similar to toothpaste in consistency.
Orange oil in gum arabic
for spray drying
11,000 1 Starting particle size: 3.87㎛ Processed particle size: 0.90㎛ 100% retention of feed oil as opposed to 95 % retention for all other competitive equipment. Smaller particles yielded dried powders w/less extractable surface oil. Increase stability.
Ketchup 2,000 1 Improved tomato cell rupture resulted in smoother, more homogenous ketchup. Small, experimental batches for R&D work are now possible
 
 
Sample Description Pressure [psi] #Pass Results & Comments
Enteral feeding emulsion Dairy based 10,000 3 Heated to 60℃ for processing then was cooled to 45℃ on outlet.Particle size reduced from 0.91㎛ to 0.13㎛ Viscosity decrease.Perceived as successful test. Survived canning (post-sterilization) step
with vitamins Filtered whey protein 5,000 1&3 Particle size reduced to 10㎛ in 1 pass and between 2 to 5㎛ in 3 passes.
Cheese slurry, 10% solids 10,000 1 Particle size reduced from 100㎛ down to 30㎛Particle size reduced to 10㎛ with large quantity of backround smaller particles.
10,000 3
 
 
Sample Description Pressure [psi] #Pass Results & Comments
25% black iron oxide in deionized water for mascara pigment 10,000 1 Grape bunches" of 10+ particulates were dispersed to primary particles. Results considered successful.
Fragrance encapsulation 10% fragrance 8% polymer 2% surfactant q.s. water 10,000 1 Desired 0.6㎛ Achieved 0.2㎛Exceptional results. Polymer encapsulates the fragrance at the droplet interface.
Bentonite clay dispersion (5%) in isopropyl Palmitate 10,000 1 Watery dispersion transformed to thick gel after processing. Clay platelets sheared apart to impart viscosity.
Dermasome?
formulations Proprietary liposome products encapsulating known cosmetic ingredients, manufactured and distributed by Microfluidics Corporation.
5,000 to 10,000 1 to 3 Processed particle size < 0.2㎛Ingredients encapsulated include:Tissue Respiratory Factors
Superoxide Dismutase
Squalane
Urea
Aloe Vera Gel
Panthenol
Allantoin
Tocopheryl Acetate
Retinyl Palmitate
Mucopolysaccharides
Evening Primrose Oil
Sodium Hyaluronate
Royal Jelly
Spleen Extract
Thymus Extract
Soluble Collagen
 
 
Sample Description Pressure [psi] #Pass Results & Comments
Lead zirconia Proprietary formulation 1000 1 2.5-5㎛ particlesFreefloating primary particles
10000 3
Green mica 7% Aqueous q.s.
White mica 11%Aqueous q.s.
6000 2 Particle size reduced from 60 to 21.6㎛ Particle size reduced from 45㎛ to 15.8㎛ Pre-dispersion step required for both samples. Large single chamber required to prevent plugs. Microfluidizer replaced sonolator that wore out every two days at a $400 repair cost
6000 1
Coarse mica 30% Aqueous q.s. 10000 2 Small flakes, uniform dispersion. Multiple passes required.
Bentonite clay 5% Aqueous q.s. 9000 2 Original particle size: 0.717㎛ -Particle size, 1 pass: 0.358㎛ -Particle size, 2 passes: 0.289㎛

Calcium sulfate hemi-hydrate 51%
DTDA 1.35% Citric Acid
0.65% Water q.s.

3000

1

Particle size: 5㎛ Particle size: 3.45㎛ Subsequent testing showed optimal pressure to be 4000psi, 1 pass

5600

1

72.1% limestone slurry in water

10000

1

Original particle size of 2.5㎛with agglomerates up to 25㎛ALL agglomerates eliminated. Primary particle size achieved.

 
 
Sample Description Pressure [psi] #Pass Results & Comments
Fe304 41.1% THF 57.5%
Soy lecithin q.s.
13000 3 Sample thickened to mayonnaise consistency. Much smoother.
Fe/Fe203 40% Cyclohexane&resin binder q.s. 1000 1 Required higher pressure occasionally to unplug interaction chamber.Agglomerate size reduced and magnetism retained. Cooling coil required.
10000 4
Fe 10% Water q.s. 10000 3 First pass broke up all of the agglomerates.Subsequent passes rendered the snake-like filaments smaller.
Iron oxide, unmilled 7000 2 Needed pre-dispersion pass. Mat'l smoother and had less agglomerates.
Iron oxide 30% 10000 1 All primary particles, no agglomerates. Pilot scale operation. Over 350 hours continuous operation without shutdown.
 
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